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Melanocytic Dermpath Basics: Melanoma
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What is pagetoid extension?
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Pagetoid melanocytosis (PM), the upward discontinuous extension of melanocytes into the superficial epidermis, although generally considered a histologic feature of malignancy, may be seen in certain benign melanocytic lesions.
What is meant by pagetoid?
Pagetoid is a term used in dermatology to refer to “upward spreading” of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
What is pagetoid spread in melanoma?
Pagetoid melanocytosis refers to the presence of solitary and small groups of melanocytes in the superficial layers of the epidermis. Although it is generally considered to be a diagnostic hallmark of melanoma, it may also be seen in certain melanocytic naevi.
What is pagetoid scatter?
The pagetoid type is characterized by scattered individual or aggregates of large pleomorphic tumor cells with a vacuolated foamy cytoplasm and nuclei with dense chromatin within the epidermis or conjunctival epithelium. From: Encyclopedia of Cancer (Third Edition), 2019.
What are Monomorphous melanocytes?
Cytologically, the monomorphous melanocytes of melanocytic nevi are in an erratic, unpredictable assortment of small and minimally larger sizes and shapes, e.g., round, oval, spindle-shaped, polygonal, plasmacytoid, ballooned, fusiform, dendritic, pagetoid and multinucleate.
What is melanocytes pagetoid spread?
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Pagetoid melanocytosis is a histological pattern defined as ascent or upward scatter of single melanocytes or small groups of melanocytes, into suprabasal layers of the epidermis, including the granular layer and above.
What does pagetoid spread mean?
Pagetoid is a term used in dermatology to refer to “upward spreading” of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
What is pagetoid spread melanoma?
Pagetoid melanocytosis refers to the presence of solitary and small groups of melanocytes in the superficial layers of the epidermis. Although it is generally considered to be a diagnostic hallmark of melanoma, it may also be seen in certain melanocytic naevi.
Is melanocytic the same as melanoma?
Melanocytic neoplasms range from benign lesions, termed melanocytic naevi, to malignant ones, termed melanomas. All originate from melanocytes, which are neural crest-derived cells that, during development, colonize the skin, eye and, to a lesser degree, a broad range of other tissues throughout the body1.
What is pagetoid extension?
Pagetoid melanocytosis (PM), the upward discontinuous extension of melanocytes into the superficial epidermis, although generally considered a histologic feature of malignancy, may be seen in certain benign melanocytic lesions.
What does pagetoid spread mean?
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Pagetoid is a term used in dermatology to refer to “upward spreading” of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.
What is pagetoid spread in melanoma?
Pagetoid melanocytosis refers to the presence of solitary and small groups of melanocytes in the superficial layers of the epidermis. Although it is generally considered to be a diagnostic hallmark of melanoma, it may also be seen in certain melanocytic naevi.
What is pagetoid spread?
Pagetoid spread is defined as an individual cell proliferation in the upper levels of the epidermis, similar to the pattern of epidermal involvement by Paget’s disease of the breast.
What are nests of melanocytes?
Nevus cells are rounded-up, nondendritic, pigment-producing cells that are derived from melanocytes. A clonal population of nevus cells can form clusters (“nests”) in the epidermis (junctional nevi), nests in the dermis (dermal nevi), or in nests located both in the epidermis and the dermis (compound nevi).
What are Monomorphous melanocytes?
Cytologically, the monomorphous melanocytes of melanocytic nevi are in an erratic, unpredictable assortment of small and minimally larger sizes and shapes, e.g., round, oval, spindle-shaped, polygonal, plasmacytoid, ballooned, fusiform, dendritic, pagetoid and multinucleate.
Does melanocytic mean melanoma?
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Melanocytes: These are the cells that can become melanoma. They normally make a brown pigment called melanin, which gives the skin its tan or brown color. Melanin protects the deeper layers of the skin from some of the harmful effects of the sun.
Is melanocytic melanoma?
Melanoma is a form of skin cancer that begins in the cells (melanocytes) that control the pigment in your skin. This illustration shows melanoma cells extending from the surface of the skin into the deeper skin layers.
Is melanocytic nevus benign or malignant?
Melanocytic nevi are benign neoplasms or hamartomas composed of melanocytes, the pigment-producing cells that constitutively colonize the epidermis.
What is the meaning of melanocytic?
(meh-LAN-oh-site) A cell in the skin and eyes that produces and contains the pigment called melanin. Enlarge.
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